CHANGES IN THE CONTENT OF INDIVIDUAL CYTOKINES IN THE BLOOD SERUM OF DOGS FOR CHRONIC PROSTATITIS WITH THE USE OF CORD BLOOD SERUM

Despite the significant spread of prostatitis in males, today the questions of substantiation of pathogenetic methods of treatment are poorly understood, which is relevant from the theoretical and practical point of view. With prostatitis in dogs, a marked cytokine imbalance is observed, which is manifested by an increase in the level of proinflammatory components of the cytokine system, while a decrease in the content of the functional antagonist IL-4. It has been established that the hyperproduction of IL-1 and TNF, their destructive effects in the prostate gland associated with their mediator properties, as pro-inflammatory cytokines are exacerbated by a significant reduction in the concentration of the opposing IL-4, indicating low inhibition of production of pro-inflammatory cytokines in the inflammatory focus. Application of the introduction of autologous cord blood serum leads to multidirectional shifts in the cytokine blood profile and indicate a decrease in the expression of proinflammatory and activation of the synthesis of anti-inflammatory cytokines on the tenth day of treatment, which generally limits the manifestation of the inflammatory response. It has been established that the use of the introduction of heterogeneous cord blood serum in dogs with prostatitis promotes the acceleration of correction of the inflammatory reaction by inhibiting the expression of proinflammatory and stimulating the synthesis of anti-inflammatory cytokines