PATHOMORPHOLOGICAL CHARACTERISTIC OF LYMPH NODES OF PIGLETS WITH SIGNS OF LATENT AND SUBCLINICAL PCV2-INFECTION

PCV2-infection disease is an infectious disease with significant economic impacts on the pig industry, which has become global in the pig population (PCVD). The main "target" for PCV-2 is the immune system, and the multiplication of PCV-2 in the cells of the immune system leads to their death and development of immunodeficiency state. The aim of the study was to determine the pathomorphological characteristics of the lymph nodes of piglets with signs of latent and subclinical PCV2-infection. To achieve this goal, monitoring studies of 275 samples of blood serum from piglets of 5-16 weeks of age out by quantitative PCR-analysis.For pathomorphological studies with the method of acute bleeding, animals with signs of latent PCV2-infection (in 1 cm³ of blood serum of 10³-10⁴ copies of the genome of PCV-2 equivalents) were slaughtered and animals with signs of subclinical PCV2-infection (in 1 cm³ of blood serum 10⁵-10⁶ copies of the gene equivalents of PCV-2) 6 heads. By anatomical preparation, the somatic and visceral lymph nodes was removed, fixed in a 10% solution of neutral formalin, poured into paraffin, sections were stained with hematoxylin and eosin and azur II eosin, and also impregnated with silver nitrate according to the method of Foote. The author, on the basis of pathohistological study, determined the structural and functional characteristics of the lymph nodes of piglets with signs of latent and subclinical PCV2-infection. It has been established that the macroscopic and microscopic characteristics of the corresponding organs in piglets with signs of latent PCV2-infection do not have significant differences from the similar characteristics of piglet nodes free of PCV2-infection. In the lymph nodes of piglets with signs of subclinical PCV2-infection, pathological macroscopic changes are characteristic of various stages of the reactive and inflammatory processes: reactive hyperplasia of the lymph node parenchyma with the transition to acute serous lymphadenitis, and, as an exception,chronic proliferative lymphadenitis in individual lymph nodes or their sites