THE MORPHOLOGY OF THE LUNGS OF CHICKENS FOR VACCINATION AGAINST INFECTIOUS BRONCHITIS AND APPLICATION OF IMMUNOMODULATOR AVESSTIM tm

The article presents data on the effect of vaccination of chickens against infectious bronchitis and application of immunomodulator Avesstim^tm on the morphology of the lungs. The postvaccinal changes in histoarchitectonics and morphometric parameters in the lungs of experimental chickens, which were directly related to the multiplicity of vaccination and were due to age characteristics of experimental animals in the postnatal period of ontogenesis, are highlighted. At the same time, immunization with vaccines (live lyophilized – strain H-120, live lyophilized – strain 4-91 and inactivated vaccine) of young chickens against infectious bronchitis is accompanied by morphological restructuring of the lungs. Thus, the results of our histological studies have shown that vaccination against infectious bronchitis of chickens there were changes in lung histostructure, especially in the 20 and 40-day age, which manifested pulmonary hyperemia, edema of the walls of pneumocapillaries and respiratory epithelium. And chickens in the application of immunomodulator Avesstim^tm only at 90-day age showed lymphoid infiltration parabronchial the walls of the lungs. The obtained results indicate that the use of chickens in the period of the withdrawal in the conditions of the hatchery, with the aim of stimulating the actions of immune response humoral immunity, immunomodulator Avesstim^tm aerosol, then by watering it at the rate of 10 ml per 1 litre of water (1:1000) for two days before and two days after the vaccination had a negative effect on lungs histoarchitectonic, but on the contrary contributed to improving their functional status. An important criterion for the morphofunctional state of the lungs is to determine the area of the respiratory part, relative to the total area of the organ. Here it should be emphasized that the area of the respiratory part of the lungs in chickens of the second experimental group of 40, 90 and 110-day age (with the use of an immunomodulator) in relation to only vaccinated, and, especially, compared with the control increases, and the connective tissue base, respectively, decreases