BIOLOGICAL PROPERTIES OF ANTI-PARASITIVE PREPARATIONS BASED ON THE MENYANTHES TRIFOLIATA L.

Economic losses from the infection of animals with helminths can be significant and they add up to undersupply, reduced quality, limited use of livestock products after the use of a number of anthelmintics, complications such as associated infections, reduced immunity, reduced nutrient input into the body of animals, and increased waste of young animals. We have developed drugs based on a three-leaf watch with antiparasitic properties. We studied the pharmaco-toxicological properties of drugs from the three-leaf watch and their effect on the physico-chemical indicators of sheep and pig meat, its nutritional and biological value. Pharmacological-toxicological characteristics of the vet drugs developed based on a medicinal plant are Menyanthes trifoliata L. and their impact on the food safety of lamb and pork have been studied. On the basis of the obtained results, it was established that according to the pharmaco-toxicological assessment parameters, the developed drug forms (infusion, decoction, vakhtotsid and meniant) according to the GOST 12.1007-76 classification belong to class IV hazard (low hazardous substances, LD₅₀ above 5000 mg/kg). They do not have local skin irritant and resorptive effects. Applied to the conjunctiva they have a mild irritant effect. The use of drugs from the Menyanthes trifoliata L. leaves does not have negative effect on biological value and safety of lamb and pork, which allows their use without restrictions. The calculation of the economic efficiency of the use of infusion and potions, Vahtocide and Meniant in parasitic diseases confirms the feasibility of using drugs from local raw materials, both for prophylactic and therapeutic purposes