The problem of modern poultry farms is arising number of hens in a limited area causing risk of microbial contamination, direct infection and transmission of diseases is increasing. The complex ADG disinfectant combines active substances with a neutral pH and low corrosion activity. It is worth-while to conduct experiments with laboratory animals to determine the toxicity of new modern disinfectants for introduction and use in poultry farms. The purpose of our studies was to determine the acute toxicity of ADG disinfectant to laboratory animals. The task was to determine the lethal and median lethal dose of ADG disinfectant. The acute toxicity of ADG was calculated by intra-gastric administration to white rats. The median lethal doses of disinfectant were determined according to G. Kerber (1931). The results obtained on white rats were LD50=3800 mg/kg and LD100=7200 mg/kg. Symptoms of ataxia, impaired motor activity, increased excitability, impaired stimuli, bradypnea, tachycardia were observed in surviving animals from the first to the tenth day. Intra-gastric administration of 0,1 % working concentration disinfectant solution caused LD50=5000 mg/kg, LD100=8400 mg/kg. During postmortem examination we detected next: the stomach is filled with mucus, the walls are thickened, the mucous membrane is hyperemic. The mucous membrane of small intestine was thickened, swollen, has catarrhal-hemorrhagic exudate. The large intestine was without visible changes. Our studies have shown that 0,1 % concentration of ADG is come under the 4th toxicity notion (low toxicity). To test the ADG disinfectant in a poultry environment is the ultimate goal of our further investigations and observations.
median lethal dose, lethal dose, laboratory animals, postmortem findings.